Here we present 5 PPI networks that were used to identify a relapse gene-signature in cT-ALL:

• Hunet: The probabilistic functional gene network Hunet v1 (http://www.functionalnet.org/).
• StringDB: Homo sapiens protein links v11 from the String database (https://string-db.org)
• Biogrid: Multi validated physical interaction v3.5 from the Biogrid database from the GeneMANIA archives (http://genemania.org)
• RegNetwork: Human regulatory relationships network from RegNetwork (http://regnetworkweb.org)
  
• Kinome: Human kinases interactions partners from AP-MS analysis (https://sec-explorer.shinyapps.io/Kinome_interactions/)

Each network is presented under two forms, the complete and pruned datasets.

Network data can be downloaded for each network as .rds files at

https://github.com/Peyronlab/Peyronlab.github.io/

Signatures detailed information

Reproducibility OS ,Reproducibility Rel.:

• Score from 0 to 3 indicating the number of cohorts on which the signature significantly predicts either overall survival or relapse.

Reproducibility qPCR:

• Score from 0 to 1 indicating the ability of the signature to predict relapse, or not.
• NA is for signatures that were not tested.

Symbol formula:

• Formula to compute patient scores using expression of given genes.

Dirgenerank parameters:

• ex: describes the initializing vector of weight (either coxph coefficients or 0)
• d: describes the balance parameter between W and ex.

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